The effect of vitamin d on memory of adult and aged ovariectomized rats
| Título | The effect of vitamin d on memory of adult and aged ovariectomized rats | pt_BR |
| Autor | Scheffer, Ândrea Kohlrausch | |
| Orientador | Budni, Josiane | |
| Resumo / Abstract | Postmenopausal women and the elderly can have their quality of life and autonomy reduced by low vitamin D levels, given the numerous metabolic changes caused by this deficiency. Therefore, we evaluated the effect of vitamin D or association on the memory of adult and aged female ovariectomized rats. The vitamin D (42 or 420 UI/kg), donepezil, or association treatment was administered for 21 days in three different experimental protocols to mimic menopause. Finally, the rats were subjected to the y-maze test to evaluate their short-term memory. The results showed that vitamin D 42, vitamin D 420, or association with vitamin D 420 plus donepezil treatment could reverse the cognitive damage caused by ovariectomy (OVX) for one month in 60 days-old rats. The vitamin D 42 plus donepezil association protected against the memory damage induced by eight months of OVX in 60 days old rats. One hundred twenty days-old rats ovariectomized for one month induced short-term spatial memory damage. The vitamin D 420 plus donepezil association administration reversed this cognitive impairment. In conclusion, the later the OVX occurs, the greater the damage and the lesser the therapeutic capacity of vitamin D. | pt_BR |
| Data de publicação | 2021-07 | |
| Tipo | Trabalho de Conclusão de Curso - TCC | pt_BR |
| Idioma | pt_BR | pt_BR |
| Palavras-chave | Vitamina D | pt_BR |
| Palavras-chave | Donepezil | pt_BR |
| Palavras-chave | Ovariectomia | pt_BR |
| Palavras-chave | Memória | pt_BR |
| Descrição | Artigo submetido ao Curso de Medicina da UNESC como requisito parcial para obtenção do Título de Bacharel em Medicina. | pt_BR |
| Data de depósito | 2021-09-08T23:10:52Z | |
| Data de disponibilização | 2021-09-08T23:10:52Z | |
| URI | http://repositorio.unesc.net/handle/1/8874 | |
| Cobertura espacial | Universidade do Extremo Sul Catarinense | pt_BR |
| Data de criação | 2021-07 |