Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine

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TítuloEffects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetaminept_BR
AutorDal Pont, Gustavo Colombo
AutorTonin, Paula Teresinha
AutorVarela, Roger Bitencourt
AutorFerreira, Camila L.
AutorGava, Fernanda Frederico
AutorAndersen, Mônica L.
AutorSoares, Jair C.
OrientadorValvassori, Samira da Silva
CoorientadorQuevedo, João Luciano de
Resumo / AbstractIt is observed alterations in levels of inflammatory mediatorsin Bipolar Disorder (BD) patients.Celecoxib (Cel) is an anti-inflammatory drug and can reduce levels of pro-inflammatory cytokines. The present study aimed to evaluate the effects of co-administration of lithium(Li) and Cel on inflammatory parameters in an animal model of mania induced by amphetamine. Were used Wistar rats, 60 days old (250–350g). The animals (n=10 per group) received D-amph (2mg/kg) or Sal intraperitoneally once a day, during 14 days. From the day 8–14, the animals from D-amph and Sal groups received via gavage Li (24 mg/kg), Cel (20 mg/kg), Li + Cel or water. The behavioral analyses were evaluated through Open Field test. Furthermore, were evaluated the levels of IL-1β, IL-4, IL-10, and TNF-α. The administration of D-amph induced hyperactivity in the rats and treatment with Li plus Cel reversed these alterations. The administration of D-amph increased the IL-4, IL-10, and TNF-α levels in the serum, frontal cortex, and striatum of rats, and treatment with Li plus Cel reversed these alterations in all tissue evaluated. The treatment with Li plus Celshowed very effective against inflammation induced by D-amph. However, more studies are necessaries to elucidate these mechanisms.pt_BR
Data de publicação2018-12
TipoDissertaçãopt_BR
Idiomapt_BRpt_BR
Palavras-chaveLítio – Uso terapêuticopt_BR
Palavras-chaveCelecoxib – Uso terapêuticopt_BR
Palavras-chaveTranstono bipolarpt_BR
Palavras-chavePsicose maníaco-depressivapt_BR
Palavras-chaveManiapt_BR
DescriçãoArtigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC.pt_BR
Data de depósito2019-04-10T13:23:48Z
Data de disponibilização2019-04-10T13:23:48Z
URIhttp://repositorio.unesc.net/handle/1/6753
Cobertura espacialUniversidade do Extremo Sul Catarinensept_BR
Data de criação2018-12

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