Maternal immune activation by LPS triggers fetal immune response and cognitive impairment in adult life

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TítuloMaternal immune activation by LPS triggers fetal immune response and cognitive impairment in adult lifept_BR
AutorTashiro, Michael Hikaru
AutorLiranço, João Lucas Garcia
AutorSimões, Lutiana Roque
AutorGeneroso, Jaqueline da Silva
AutorCollodel, Allan
AutorDominguini, Diogo
AutorZugno, Alexandre Ioppi
AutorQuevedo, João Luciano de
OrientadorBarichello, Tatiana
CoorientadorJornada, Luciano Kurtz
Resumo / AbstractThere is growing evidence that maternal infection during pregnancy results in acute and chronic changes in developmental context structure and function of the central nervous system (CNS) in the fetus. These changes increase the risk of premature birth, mental retardation and neuropsychiatric disorders such as autism, attention deficit disorder, major depressive disorder, bipolar disorder and schizophrenia. In this study we evaluated BBB integrity in the hippocampus and cortex at 6, 12 and 24 hours of the Wistar female pregnant after injection of LPS and the integrity of placental barrier in the structures placenta and fetus brain. Pregnant Wistar rat received an intraperitoneal injection of LPS (0.25 mg/Kg) or PBS on gestational day 15. At 6, 12, and 24h following MIA or PBS injections, pregnant dams were anesthetized. Brain fetus, placenta, and amniotic fluid were collected. Blood-brain barrier (BBB) and placental- barrier (PB) integrity were evaluated. On postnatal 55 offspring from MIA and PBS were subjected to the habituation to the open field and object recognition tasks. For the behavioural test, evaluated the influence of MIA on habituation memory, recognition memory and covered distance in the adulthood of prole of pregnant rats after the injection of LPS. Our study demonstrates that maternal LPS was able to break through the BBB of pregnant rats and offspring, generating cognitive deficits in offspring including locomotor disorders and reduced habituation capacity and recognition memory.pt_BR
Data de publicação2016-07
TipoTrabalho de Conclusão de Curso - TCCpt_BR
Idiomapt_BRpt_BR
Palavras-chaveAtivação immune maternalpt_BR
Palavras-chaveLipopolissacarídeopt_BR
Palavras-chaveComprometimento cognitivopt_BR
Palavras-chaveBarreira hematoencefálicapt_BR
Palavras-chaveBarreira placentáriapt_BR
DescriçãoArtigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESCpt_BR
Data de depósito2018-12-10T12:36:59Z
Data de disponibilização2018-12-10T12:36:59Z
URIhttp://repositorio.unesc.net/handle/1/6424
Cobertura espacialUniversidade do Extremo Sul Catarinensept_BR
Data de criação2016-07

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