Use este identificador para citar ou linkar para este item: http://repositorio.unesc.net/handle/1/6753
Título: Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine
Autor(es): Dal Pont, Gustavo Colombo
Tonin, Paula Teresinha
Varela, Roger Bitencourt
Ferreira, Camila L.
Gava, Fernanda Frederico
Andersen, Mônica L.
Soares, Jair C.
Orientador(es): Valvassori, Samira da Silva
Co-orientador: Quevedo, João Luciano de
Palavras-chave: Lítio – Uso terapêutico
Celecoxib – Uso terapêutico
Transtono bipolar
Psicose maníaco-depressiva
Mania
Descrição: Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC.
Resumo: It is observed alterations in levels of inflammatory mediatorsin Bipolar Disorder (BD) patients.Celecoxib (Cel) is an anti-inflammatory drug and can reduce levels of pro-inflammatory cytokines. The present study aimed to evaluate the effects of co-administration of lithium(Li) and Cel on inflammatory parameters in an animal model of mania induced by amphetamine. Were used Wistar rats, 60 days old (250–350g). The animals (n=10 per group) received D-amph (2mg/kg) or Sal intraperitoneally once a day, during 14 days. From the day 8–14, the animals from D-amph and Sal groups received via gavage Li (24 mg/kg), Cel (20 mg/kg), Li + Cel or water. The behavioral analyses were evaluated through Open Field test. Furthermore, were evaluated the levels of IL-1β, IL-4, IL-10, and TNF-α. The administration of D-amph induced hyperactivity in the rats and treatment with Li plus Cel reversed these alterations. The administration of D-amph increased the IL-4, IL-10, and TNF-α levels in the serum, frontal cortex, and striatum of rats, and treatment with Li plus Cel reversed these alterations in all tissue evaluated. The treatment with Li plus Celshowed very effective against inflammation induced by D-amph. However, more studies are necessaries to elucidate these mechanisms.
Idioma: Português (Brasil)
Tipo: Dissertação
Data da publicação: Dez-2018
URI: http://repositorio.unesc.net/handle/1/6753
Aparece nas coleções:Trabalho de Conclusão de Curso (MED)

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